Phuputso e ncha e fana ka maikutlo a hore li-astrocyte, mofuta oa sele ea boko, li bohlokoa bakeng sa ho hokahanya amyloid-β le mekhahlelo ea pele ea tau pathology.Karyna Bartashevich/Stocksy
- Reactive astrocyte, mofuta oa sele ea boko, e ka thusa bo-rasaense ho utloisisa hore na ke hobane'ng ha batho ba bang ba nang le kelello e phetseng hantle le li-amyloid-β deposits bokong ba bona ba sa hlahise matšoao a mang a lefu la Alzheimer's, joalo ka liprotheine tsa tau tse tangled.
- Phuputso e nang le barupeluoa ba fetang 1,000 e ile ea sheba li-biomarker 'me ea fumana hore amyloid-β e ne e amahanngoa feela le ho eketseha ha maemo a tau ho batho ba neng ba e-na le matšoao a astrocyte reactivity.
- Liphuputso li fana ka maikutlo a hore li-astrocyte li bohlokoa bakeng sa ho hokahanya amyloid-β le mekhahlelo ea pele ea tau pathology, e ka fetolang mokhoa oa ho hlalosa lefu la pele la Alzheimer.
Ho bokellana ha li-amyloid plaque le liprotheine tsa tau bokong ke khale ho nkoa e le sesosa se ka sehloohong saLefu la Alzheimer (AD).
Nts'etsopele ea lithethefatsi e na le tšekamelo ea ho shebana le ho lebisa tlhokomelo ho amyloid le tau, ho hlokomoloha karolo e ka bang teng ea mekhoa e meng ea boko, joalo ka tsamaiso ea neuroimmune.
Hona joale, liphuputso tse ncha tse tsoang Univesithing ea Pittsburgh School of Medicine li fana ka maikutlo a hore li-astrocyte, e leng lisele tsa boko tse bōpehileng joaloka naleli, li bapala karolo ea bohlokoa ho tseba hore na Alzheimer's e tsoela pele joang.
Mohloli o Tšepahalang oa Astrocytesli ngata liseleng tsa boko.Ho ipapisitsoe le lisele tse ling tsa glial, lisele tse lulang bokong tsa 'mele tsa ho itšireletsa mafung, li-astrocyte li tšehetsa methapo ea kutlo ka ho li fa limatlafatsi, oksijene le tšireletso khahlanong le likokoana-hloko.
Pejana karolo ea li-astrocyte puisanong ea neuronal e ne e hlokomolohuoa kaha lisele tsa glial ha li tsamaise motlakase joalo ka li-neurone.Empa thuto ea Univesithi ea Pittsburg e phephetsa mohopolo ona mme e fana ka leseli mabapi le karolo ea bohlokoa ea li-astrocyte bophelong ba boko le mafu.
Liphuputso li phatlalalitsoe haufinyane hoNature MedicineTrusted Source.
Patlisiso e fetileng e fana ka maikutlo a hore ho sitisoa ha lits'ebetso tsa boko ho feta moroalo oa amyloid, joalo ka ho ruruha ha boko bo eketsehileng, ho ka bapala karolo ea bohlokoa ho qaleng tatellano ea lefu la neuronal e lebisang ho fokotseha ho potlakileng ha kelello ho Alzheimer's.
Phuputsong ena e ncha, bafuputsi ba ile ba etsa liteko tsa mali ho barupeluoa ba 1,000 ba tsoang lithutong tse tharo tse arohaneng tse amanang le batho ba baholo ba phelang hantle ba nang le kelello ba nang le li-amyloid buildup.
Ba ile ba sekaseka lisampole tsa mali ho lekola li-biomarker tsa astrocyte reactivity, haholo-holo glial fibrillary acidic protein (GFAP), hammoho le boteng ba pathological tau.
Bafuputsi ba fumane hore ke ba nang le moroalo oa li-amyloid le matšoao a mali a bontšang ts'ebetso e sa tloaelehang ea astrocyte kapa reactivity ba ka 'nang ba ba le matšoao a Alzheimer's nakong e tlang.
Nako ea poso: Jun-08-2023